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1.
Chirurgie (Heidelb) ; 95(5): 375-381, 2024 May.
Artigo em Alemão | MEDLINE | ID: mdl-38427034

RESUMO

BACKGROUND: Intestinal transplantation (ITx) is the only causal treatment for complicated chronic intestinal failure after mesenteric ischemia and impending failure of parenteral supplementation. Isolated or combined ITx with the inclusion of the intestine is associated with demanding immunological, perioperative and infection associated challenges. AIM: The characterization of chronic intestinal failure, the indications, transplant survival, transplantation techniques and success rates. MATERIAL AND METHODS: Collection, summary and critical appraisal of international guidelines, the guidelines of the German Medical Chamber, and the international literature. RESULTS: The first successful ITx were performed in 1987 and 1988 at the University of Kiel Germany and the University of Pittsburgh, USA. The number of ITx rose continuously but in phases from the end of the 1990s to over 200 per year but has currently decreased to 100-150 per year due to optimized intestinal rehabilitation. While the 1­year and 3­year transplant survival rates were 30% and 20% before 1991, they increased in phases up to 60% and 50%, respectively, after 1995 and have now achieved almost 80% and 70%, respectively. CONCLUSION: The substantial improvement in the results of ITx can be partly explained by progress in operative techniques, intensive care medicine and a better understanding of mucosal immunity; however, optimized strategies in immunosuppression as well as prevention of infectious diseases and malignancies have also made decisive contributions.


Assuntos
Enteropatias , Insuficiência Intestinal , Isquemia Mesentérica , Síndrome do Intestino Curto , Humanos , Síndrome do Intestino Curto/cirurgia , Síndrome do Intestino Curto/complicações , Isquemia Mesentérica/cirurgia , Isquemia Mesentérica/complicações , Intestinos/cirurgia , Enteropatias/complicações , Enteropatias/cirurgia , Doença Crônica
2.
Obes Facts ; 17(2): 211-216, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-38246162

RESUMO

INTRODUCTION: Acute mesenteric ischemia (AMI) is a rare but lethal disease. Mesenteric vein thrombosis (VAMI) is a subtype of AMI. Morbid obesity is usually accompanied by hypertension, hyperlipidemia, or diabetes mellitus, which are risk factors associated with AMI. CASE PRESENTATION: We present a 28-year-old man with VAMI post-laparoscopic sleeve gastrectomy. He was first misdiagnosed with intestinal obstruction. Superior VAMI was confirmed after computed tomography angiography. Laparotomy, resection of the necrotic small bowel, and ostomy were performed immediately. CONCLUSION: Patients with morbid obesity accompanied by hypertension, hyperlipidemia, or diabetes mellitus have a high risk of AMI. Abdominal pain with sudden onset should be considered AMI. Anticoagulation therapy post-sleeve gastrectomy might help reduce the incidence of AMI.


Assuntos
Diabetes Mellitus , Hiperlipidemias , Hipertensão , Laparoscopia , Isquemia Mesentérica , Obesidade Mórbida , Trombose Venosa , Masculino , Humanos , Adulto , Trombose Venosa/diagnóstico por imagem , Trombose Venosa/etiologia , Complicações Pós-Operatórias/etiologia , Isquemia Mesentérica/etiologia , Isquemia Mesentérica/complicações , Obesidade Mórbida/complicações , Obesidade Mórbida/cirurgia , Veias Mesentéricas/diagnóstico por imagem , Laparoscopia/efeitos adversos , Gastrectomia/efeitos adversos , Gastrectomia/métodos , Diabetes Mellitus/etiologia , Hiperlipidemias/complicações , Hiperlipidemias/cirurgia , Hipertensão/complicações
3.
Nursing ; 54(2): 48-55, 2024 Feb 01.
Artigo em Inglês | MEDLINE | ID: mdl-38271132

RESUMO

ABSTRACT: Mesenteric ischemia is a group of disorders requiring prompt identification, supportive care, and treatment. Chronic mesenteric ischemia can develop into acute mesenteric ischemia, which has high mortality. Acute mesenteric ischemia can be occlusive (caused by arterial embolism, arterial thrombosis, or mesenteric venous thrombosis) or nonocclusive, with treatment depending on the underlying cause.


Assuntos
Embolia , Isquemia Mesentérica , Trombose , Humanos , Isquemia Mesentérica/terapia , Isquemia Mesentérica/complicações , Doença Aguda , Trombose/etiologia , Embolia/complicações , Isquemia/complicações
4.
Updates Surg ; 76(1): 193-199, 2024 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-37278935

RESUMO

Porto-mesenteric venous thrombosis (PMVT) is a rare complication that is encountered in less than 1% of patients following laparoscopic sleeve gastrectomy (LSG). This condition could be conservatively managed in stable patients with no evidence of peritonitis or bowel wall ischemia. Nonetheless, conservative management may be followed by ischemic small bowel stricture, which is poorly reported in the literature. Herein, we present our experience regarding three patients who presented with manifestations of jejunal stricture after initial successful conservative management of PMVT. Retrospective analysis of patients who developed jejunal stenosis as a sequela after LSG. The three included patients had undergone LSG with an uneventful post-operative course. All of them developed PMVT that was conservatively managed mainly by anticoagulation. After they were discharged, all of them returned with manifestations of upper bowel obstruction. Upper gastrointestinal series and abdominal computed tomography confirmed the diagnosis of jejunal stricture. The three patients were explored via laparoscopy, and resection anastomosis of the stenosed segment was performed. Bariatric surgeons should be aware of the association between PMVT, following LSG, and ischemic bowel strictures. That should help in the rapid diagnosis of the rare and difficult entity.


Assuntos
Laparoscopia , Isquemia Mesentérica , Obesidade Mórbida , Trombose Venosa , Humanos , Constrição Patológica/etiologia , Estudos Retrospectivos , Trombose Venosa/etiologia , Trombose Venosa/cirurgia , Obesidade Mórbida/cirurgia , Obesidade Mórbida/complicações , Laparoscopia/efeitos adversos , Laparoscopia/métodos , Progressão da Doença , Isquemia Mesentérica/complicações , Gastrectomia/efeitos adversos , Gastrectomia/métodos
5.
J Vasc Surg Venous Lymphat Disord ; 12(2): 101727, 2024 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-38043681

RESUMO

OBJECTIVE: Thrombi in the axial calf veins have quite different anatomical and physiological characteristics from that in the muscular calf veins, but their treatment was usually addressed in the same manner. We performed a meta-analysis of randomized and cohort studies to compare clinical outcomes among patients with isolated axial vs muscular calf deep vein thrombosis (DVT). METHODS: Recurrent venous thromboembolism (VTE) was selected as the primary outcome. Resolution, proximal propagation of calf DVT, pulmonary embolism (PE), major bleeds, and clinically relevant non-major bleeds were separately analyzed as secondary outcomes. Data were pooled and compared with risk ratio (RR) and 95% confidence interval (CI). RESULTS: Thirteen studies, consisting of 4889 patients, met the inclusion criteria and were included for analysis. A greater rate of recurrent VTE (FE model: RR, 1.23; 95% CI, 1.00-1.53; I2 = 29%), resolution (FE model: RR, 1.32; 95% CI, 1.01-1.72; I2 = 31%), proximal propagation (FE model: RR, 1.63; 95% CI, 1.10-2.41; I2 = 40%), and PE (FE model: RR, 2.79; 95% CI, 1.31-5.95; I2 = 0%) in the axial group compared with the muscular group. There was no difference in the pooled estimates for major bleeds (FE model: RR, 1.09; 95% CI, 0.61-1.95; I2 = 0%), and clinically relevant non-major bleeds (FE model: RR, 1.80; 95% CI, 0.93-3.48) in the axial and muscular arms. CONCLUSIONS: Patients with calf DVT limited to muscular veins might have a lower rate of recurrent VTE, resolution, proximal propagation, and PE vs those with axial calf vein involvement and exhibited similar safety outcomes.


Assuntos
Isquemia Mesentérica , Embolia Pulmonar , Tromboembolia Venosa , Trombose Venosa , Humanos , Anticoagulantes/efeitos adversos , Tromboembolia Venosa/diagnóstico , Tromboembolia Venosa/terapia , Tromboembolia Venosa/induzido quimicamente , Isquemia Mesentérica/complicações , Trombose Venosa/diagnóstico por imagem , Trombose Venosa/terapia , Embolia Pulmonar/terapia , Embolia Pulmonar/complicações , Hemorragia/induzido quimicamente
6.
Medicina (Kaunas) ; 59(11)2023 Oct 24.
Artigo em Inglês | MEDLINE | ID: mdl-38003939

RESUMO

Background: Acute mesenteric ischemia (AMI) is a life-threatening condition, and in 50% of patients, AMI is caused by acute superior mesenteric artery (SMA) embolism. Endovascular treatment is increasingly being considered the primary modality in selected cases. Many studies have reported that percutaneous aspiration embolectomy using a guiding catheter and thrombolysis with recombinant tissue plasminogen activator (rtPA) are effective in treating SMA embolism. However, no reports on treating SMA embolism using rtPA administered via a microcatheter exist. Case presentation: A 64-year-old man with underlying atrial fibrillation presented with acute SMA embolism revealed using computed tomography (CT). rtPA (total 3 mg) was carefully administered into the occluded SMA through a microcatheter. No complications occurred, and complete revascularization of the SMA was revealed on follow-up CT. Conclusions: Compared with previous reports, this case report reveals that successful revascularization can be achieved using rtPA administered via a microcatheter, with a low dose of rtPA and a short duration of thrombolysis.


Assuntos
Embolia , Gastroenteropatias , Isquemia Mesentérica , Oclusão Vascular Mesentérica , Masculino , Humanos , Pessoa de Meia-Idade , Ativador de Plasminogênio Tecidual/uso terapêutico , Artéria Mesentérica Superior , Resultado do Tratamento , Oclusão Vascular Mesentérica/etiologia , Oclusão Vascular Mesentérica/terapia , Embolia/complicações , Embolia/tratamento farmacológico , Isquemia Mesentérica/complicações , Isquemia Mesentérica/terapia , Terapia Trombolítica/métodos , Gastroenteropatias/complicações
7.
Clin Med (Lond) ; 23(5): 521-524, 2023 09.
Artigo em Inglês | MEDLINE | ID: mdl-37775160

RESUMO

Acute mesenteric ischaemia is divided into different clinical entities which are usually considered separately. Here we report a case of acute mesenteric ischaemia complicated with acute anterior myocardial infarction. The clinical picture suggested that non-occlusive mesenteric ischaemia and acute mesenteric arterial thrombosis were both present in this case. Thus, non-occlusive and occlusive ischaemia may coexist in a coordinated and perceptible pattern.


Assuntos
Isquemia Mesentérica , Infarto do Miocárdio , Humanos , Isquemia Mesentérica/diagnóstico , Isquemia Mesentérica/complicações , Isquemia/diagnóstico , Isquemia/etiologia , Infarto do Miocárdio/complicações , Infarto do Miocárdio/diagnóstico
8.
Medicine (Baltimore) ; 102(32): e34549, 2023 Aug 11.
Artigo em Inglês | MEDLINE | ID: mdl-37565896

RESUMO

RATIONALE: Acute mesenteric ischemia due to superior mesenteric vein (SMV) thrombosis is a rare yet potentially life-threatening emergency. Our case report explores this condition in the context of a patient with liver cirrhosis due to Wilson disease. We specifically highlight the complex derangement of the coagulative balance in liver cirrhosis. PATIENT CONCERNS: A 34-year-old female with Wilson disease-related cirrhosis presented with intractable abdominal pain, nausea, and vomiting that showed no response to antispasmodic medication. DIAGNOSES: A contrast-enhanced abdominal computed tomography scan and Doppler ultrasound confirmed an intraluminal filling defect in the SMV, leading to the diagnosis of SMV thrombosis. INTERVENTIONS: Prompt anticoagulation, intravenous fluids, and an antibiotic were initiated. Surgical consultation recommended conservative therapy with close monitoring. OUTCOMES: Over the following 2 days, the patient's condition improved considerably, with almost complete resolution of her symptoms. Genetic testing identified a 4G/4G homozygous genotype of the plasminogen activator inhibitor 1 gene, associated with a higher risk of thrombosis in the vessels of internal organs. After 2 months of sustained anticoagulant therapy, a follow-up contrast-enhanced computed tomography scan revealed near-complete recanalization of the SMV, and the patient remained symptom-free. LESSONS: This case underscores the importance of early detection and treatment of acute mesenteric ischemia in patients with liver cirrhosis, as well as the potential role of genetic factors in thrombosis.


Assuntos
Degeneração Hepatolenticular , Isquemia Mesentérica , Trombose , Trombose Venosa , Humanos , Feminino , Adulto , Isquemia Mesentérica/complicações , Isquemia Mesentérica/tratamento farmacológico , Trombose Venosa/complicações , Trombose Venosa/diagnóstico , Degeneração Hepatolenticular/complicações , Veias Mesentéricas/diagnóstico por imagem , Resultado do Tratamento , Trombose/complicações , Cirrose Hepática/complicações
9.
Br J Radiol ; 96(1151): 20230232, 2023 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-37493183

RESUMO

Radiologists play a central role in the diagnostic and prognostic evaluation of patients with acute mesenteric ischaemia (AMI). Unfortunately, more than half of AMI patients undergo imaging with no prior suspicion of AMI, making identifying this disease even more difficult. A confirmed diagnosis of AMI is ideally made with dynamic contrast-enhanced CT but the diagnosis may be made on portal-venous phase images in appropriate clinical settings. AMI is diagnosed on CT based on the identification of vascular impairment and bowel ischaemic injury with no other cause. Moreover, radiologists must evaluate the probability of bowel necrosis, which will influence the treatment options.AMI is usually separated into different entities: arterial, venous, non-occlusive and ischaemic colitis. Arterial AMI can be occlusive or stenotic, the dominant causes being atherothrombosis, embolism and isolated superior mesenteric artery (SMA) dissection. The main finding in the bowel is decreased wall enhancement, and necrosis can be suspected when dilatation >25 mm is identified. Venous AMI is related to superior mesenteric vein (SMV) thrombosis as a result of a thrombophilic state (acquired or inherited), local injury (cancer, inflammation or trauma) or underlying SMV insufficiency. The dominant features in the bowel are hypoattenuating wall thickening with submucosal oedema. Decreased enhancement of the involved bowel suggests necrosis. Non-occlusive mesenteric ischaemia (NOMI) is related to impaired SMA flow following global hypoperfusion associated with low-flow states. There are numerous findings in the bowel characterised by diffuse extension. An absence of bowel enhancement and a thin bowel wall suggest necrosis in NOMI. Finally, ischaemic colitis is a sub-entity of arterial AMI and reflects localised colon ischaemia-reperfusion injury. The main CT finding is a thickened colon wall with fat stranding, which seems to be unrelated to SMA or inferior mesenteric artery lesions. A precise identification and description of vascular lesions, bowel involvement and features associated with transmural necrosis is needed to determine patient treatment and outcome.


Assuntos
Colite Isquêmica , Enteropatias , Isquemia Mesentérica , Acidente Vascular Cerebral , Humanos , Isquemia Mesentérica/diagnóstico por imagem , Isquemia Mesentérica/complicações , Colite Isquêmica/complicações , Intestinos/diagnóstico por imagem , Necrose , Estudos Retrospectivos
10.
Nurse Pract ; 48(6): 17-25, 2023 06 01.
Artigo em Inglês | MEDLINE | ID: mdl-37227311

RESUMO

ABSTRACT: Mesenteric ischemia is a group of disorders requiring prompt identification, supportive care, and treatment. Chronic mesenteric ischemia can develop into acute mesenteric ischemia, which has high mortality. Acute mesenteric ischemia can be occlusive (caused by arterial embolism, arterial thrombosis, or mesenteric venous thrombosis) or nonocclusive, with treatment depending on the underlying cause.


Assuntos
Embolia , Isquemia Mesentérica , Trombose , Humanos , Isquemia Mesentérica/complicações , Isquemia Mesentérica/terapia , Doença Aguda , Trombose/etiologia , Embolia/complicações , Isquemia/complicações
11.
Int J Colorectal Dis ; 38(1): 146, 2023 May 29.
Artigo em Inglês | MEDLINE | ID: mdl-37247011

RESUMO

PURPOSE: The prognostic impact of disseminated intravascular coagulation (DIC) in surgical patients with non-occlusive mesenteric ischemia (NOMI) is unclear. This study aimed to confirm the association between postoperative DIC and prognosis and to identify preoperative risk factors associated with postoperative DIC. METHODS: This retrospective study included 52 patients who underwent emergency surgery for NOMI between January 2012 and March 2022. Kaplan-Meier curve analysis with the log-rank test was used to compare 30-day survival and hospital survival between patients with and without postoperative DIC. In addition, univariable and multivariable logistic regression analyses were performed to identify the preoperative risk factors for postoperative DIC. RESULTS: The 30-day and hospital mortality rates were 30.8% and 36.5%, respectively, and the incidence rate of DIC was 51.9%. Compared to patients without DIC, patients with DIC showed significantly lower rates of 30-day survival (41.5% vs 96%, log-rank P < 0.001) and hospital survival (30.2% vs 86.4%, log-rank, P < 0.001). Logistic regression analyses showed that the Japanese Association for Acute Medicine (JAAM) DIC score (OR = 2.697; 95% CI, 1.408-5.169; P = 0.003) and Sequential Organ Failure Assessment (SOFA) score (OR = 1.511; 95% CI, 1.111-2.055; P = 0.009) were independent risk factors for postoperative DIC in surgical patients with NOMI. CONCLUSION: The development of postoperative DIC is a significant prognostic factor for 30-day and hospital mortalities in surgical patients with NOMI. In addition, the JAAM DIC score and SOFA score have a high discriminative ability for predicting the development of postoperative DIC.


Assuntos
Coagulação Intravascular Disseminada , Isquemia Mesentérica , Sepse , Humanos , Estudos Retrospectivos , Coagulação Intravascular Disseminada/complicações , Isquemia Mesentérica/complicações , Isquemia Mesentérica/cirurgia , Prognóstico , Fatores de Risco
12.
Dig Dis Sci ; 68(6): 2597-2603, 2023 06.
Artigo em Inglês | MEDLINE | ID: mdl-37027107

RESUMO

BACKGROUND: Inflammatory bowel disease (IBD) has been associated with an increased risk of thromboembolic vascular complications. Although studies from the National Inpatient Sample (NIS) examined this association to some extent, sub-stratification for Crohn's disease (CD) and ulcerative colitis (UC) in larger studies is lacking. The aims of this study were to utilize the NIS to determine the prevalence of thromboembolic events in inpatients with IBD compared to in patients without IBD and to explore the inpatient outcomes like morbidity, mortality, and resource utilization in patients with IBD and thromboembolic events as stratified by disease subtype. METHODS: This was a retrospective observational study using the NIS 2016. All patients with ICD10-CM codes for IBD were included. Patients with thromboembolic events were identified using diagnostic ICD codes and stratified into 4 categories: (1) Deep vein thrombosis (DVT), (2) Pulmonary embolism (PE), (3) Portal vein thrombosis (PVT), and (4) Mesenteric ischemia, which were then sub-stratified for CD and UC. The primary outcome was the inpatient prevalence and odds of thromboembolic events in patients with IBD compared to without IBD. Secondary outcomes were inpatient morbidity, mortality, resource utilization, colectomy rates, hospital length of stay (LOS), and total hospital costs and charges compared to patients with IBD and thromboembolic events. RESULTS: A total of 331,950 patients with IBD were identified, of who 12,719 (3.8%) had an associated thromboembolic event. For the primary outcome, after adjusting for confounders, inpatients with IBD had higher adjusted odds of DVT (aOR 1.59, p < 0.001), PE (aOR 1.20, p < 0.001), PVT (aOR 3.18, p < 0.001) and mesenteric ischemia (aOR 2.49, p < 0.001) compared to inpatients without IBD, an observation which was confirmed for both patients with CD and UC. Inpatients with IBD and associated DVT, PE and mesenteric ischemia had higher morbidity, mortality, odds of colectomy, cost, and charges. CONCLUSIONS: Inpatients with IBD have higher odds of associated thromboembolic disorders compared to patients without IBD. Furthermore, inpatients with IBD and thromboembolic events have significantly higher mortality, morbidity, colectomy rates and resource utilization. For these reasons, increased awareness and specialized strategies for the prevention and management of thromboembolic events should be considered in inpatients with IBD.


Assuntos
Colite Ulcerativa , Doença de Crohn , Doenças Inflamatórias Intestinais , Isquemia Mesentérica , Embolia Pulmonar , Trombose Venosa , Humanos , Isquemia Mesentérica/complicações , Doenças Inflamatórias Intestinais/complicações , Doenças Inflamatórias Intestinais/epidemiologia , Colite Ulcerativa/complicações , Colite Ulcerativa/epidemiologia , Doença de Crohn/complicações , Doença de Crohn/epidemiologia , Doença de Crohn/terapia , Tempo de Internação , Trombose Venosa/etiologia , Trombose Venosa/complicações , Embolia Pulmonar/etiologia , Embolia Pulmonar/complicações
13.
Medicine (Baltimore) ; 102(17): e33586, 2023 Apr 25.
Artigo em Inglês | MEDLINE | ID: mdl-37115070

RESUMO

RATIONALE: Superior mesenteric artery (SMA) stenosis, as a common arterial disease, if coexists with other possible causes of abdominal pain, is complicated, which may require not only conservative treatment but also surgical intervention. PATIENT CONCERNS: A 64-year-old male patient who was admitted to our hospital with pain located around the umbilicus and right lower quadrant for 12 hours. DIAGNOSIS: SMA stenosis was initially diagnosed. After balloon dilatation of SMA and stent implantation, computed tomography angiography reexamination showed that the stent was migrated and the stenosis reoccurred. During the ileocecal resection and enterolysis, the necrotic bowel was found and cut open, and the intestinal fistula was found. Combined with his abdominal surgery history, the patient was diagnosed with complicated SMA stenosis with intestinal necrosis. INTERVENTIONS: The balloon dilatation of SMA and stent implantation was performed. Because the stent was migrated and the stenosis reoccurred, so a balloon stent was implanted in the proximal stenosis of SMA again. The patient's symptoms were relieved and reoccurred again. The ileocecal resection and enterolysis were performed. OUTCOMES: The computed tomography angiography showed that the stents were well deployed and unobstructed after 9 months follow-up. LESSONS: When dealing with undetermined abdominal pain that especially has something to do with mesenteric artery ischemia, if there coexists with other possible causes of abdominal pain, we cannot only focus on vascular diseases. We should be vigilant, integrate multiple factors and their interactions to guarantee the accuracy and timeliness of diagnosis and therapy.


Assuntos
Gastroenteropatias , Enteropatias , Isquemia Mesentérica , Doença Arterial Periférica , Masculino , Humanos , Pessoa de Meia-Idade , Artéria Mesentérica Superior/diagnóstico por imagem , Artéria Mesentérica Superior/cirurgia , Constrição Patológica/complicações , Stents/efeitos adversos , Enteropatias/complicações , Gastroenteropatias/complicações , Dor Abdominal/etiologia , Doença Arterial Periférica/complicações , Necrose/complicações , Resultado do Tratamento , Isquemia Mesentérica/complicações , Isquemia Mesentérica/cirurgia
14.
J Vasc Surg Venous Lymphat Disord ; 11(4): 731-740, 2023 07.
Artigo em Inglês | MEDLINE | ID: mdl-36906102

RESUMO

OBJECTIVE: Mesenteric venous thrombosis (MVT) is a rare cause of acute surgical abdomen, with high mortality. The aim of this study was to analyze long-term outcomes and possible factors influencing its prognosis. METHODS: All patients who underwent urgent surgery for MVT from 1990 to 2020 in our center were reviewed. Epidemiological, clinical, and surgical data; postoperative outcomes; origin of thrombosis; and long-term survival were analyzed. Patients were divided into two groups: primary MVT (hypercoagulability disorders or idiopathic MVT) and secondary MVT (underlying disease). RESULTS: Fifty-five patients, 36 (65.5%) men and 19 (34.5%) women, mean age 66.7 years (standard deviation: ±18.0 years), underwent surgery for MVT. Arterial hypertension (63.6%) was the most prevalent comorbidity. Regarding the possible origin of MVT, 41 (74.5%) patients had primary MVT and 14 (25.5%) patients had secondary MVT. From these, 11 (20%) patients had hypercoagulable states, 7 (12.7%) had neoplasia, 4 (7.3%) had abdominal infection, 3 (5.5%) had liver cirrhosis, 1 (1.8%) patient had recurrent pulmonary thromboembolism, and 1 (1.8%) had deep venous thrombosis. Computed tomography was diagnostic of MVT in 87.9% of the cases. Intestinal resection was performed in 45 patients due to ischemia. Only 6 patients (10.9%) had no complication, 17 patients (30.9%) presented minor complications, and 32 patients (58.2%) presented severe complications according to the Clavien-Dindo classification. Operative mortality was 23.6%. In univariate analysis, comorbidity measured by the Charlson index (P = .019) and massive ischemia (P = .002) were related to operative mortality. The probability of being alive at 1, 3, and 5 years was 66.4%, 57.9%, and 51.0%, respectively. In univariate analysis of survival, age (P < .001), comorbidity (P < .001), and type of MVT (P = .003) were associated with a good prognosis. Age (P = .002; hazard ratio: 1.05, 95% confidence interval: 1.02-1.09) and comorbidity (P = .019; hazard ratio: 1.28, 95% confidence interval: 1.04-1.57) behaved as independent prognostic factors for survival. CONCLUSIONS: Surgical MVT continues to show high lethality. Age and comorbidity according to the Charlson index correlate well with mortality risk. Primary MVT tends to have a better prognosis than secondary MVT.


Assuntos
Isquemia Mesentérica , Trombofilia , Trombose , Trombose Venosa , Masculino , Humanos , Feminino , Idoso , Isquemia Mesentérica/diagnóstico por imagem , Isquemia Mesentérica/cirurgia , Isquemia Mesentérica/complicações , Trombose Venosa/diagnóstico por imagem , Trombose Venosa/cirurgia , Trombose Venosa/complicações , Trombofilia/complicações , Isquemia/complicações , Estudos Retrospectivos
16.
Am Surg ; 89(8): 3514-3515, 2023 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-36867159

RESUMO

Acute mesenteric ischemia (AMI) is associated with a high mortality and morbidity. There are limited studies on the presentation and management of elderly dementia patients with AMI. The following case of an 88-year-old female with dementia presenting with AMI highlights the challenges in the care of elderly dementia patients with AMI, the importance of identifying risk factors and hallmarks of acute mesenteric ischemia early in the clinical course, and suggests that aggressive workup with diagnostic laparoscopy is crucial to timely diagnosis and effective care.


Assuntos
Demência , Isquemia Mesentérica , Feminino , Humanos , Idoso , Idoso de 80 Anos ou mais , Isquemia Mesentérica/cirurgia , Isquemia Mesentérica/complicações , Dor Abdominal/diagnóstico , Dor Abdominal/etiologia , Fatores de Risco , Demência/complicações , Isquemia/cirurgia , Isquemia/complicações , Estudos Retrospectivos
17.
Scand J Surg ; 112(2): 77-85, 2023 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-36755514

RESUMO

BACKGROUND AND OBJECTIVE: Acute mesenteric ischemia (AMI) has a high mortality rate due to the development of bowel necrosis. Patients are often ruled outside active care if a large proportion of small bowel is necrotic. With the development of treatment for short bowel syndrome (SBS) and intestinal transplantation methods, long-term survival is possible even after extensive small bowel resections. This study aims to assess the incidence of SBS and potentially suitable candidates for intestinal transplantation among patients treated for AMI. METHODS: This population-based retrospective study comprised patients aged less than 70 years and diagnosed with AMI between January 2006 and October 2020 in Helsinki and Uusimaa health care district, Finland. RESULTS: Altogether, AMI was diagnosed in 711 patients, of whom 133 (19%) were aged below 70. An intervention was performed in 110 (83%) patients. Of these 133 patients, 16 (12%) were ruled outside active treatment due to extensive small bowel necrosis at exploratory laparotomy, of whom 6 (5%) were potentially suitable for intestinal transplantation. Two patients were considered as potential candidates for intestinal transplantation at bowel resection but died of AMI. Nine (7%) patients needed parenteral nutrition after resection, and two of them (2%) developed SBS. Only one patient needed long-term parenteral nutrition after hospital discharge. This patient remained dependent on parenteral nutrition but died before evaluation of intestinal transplantation could be carried out while the other patient was able to return to enteral nutrition. CONCLUSIONS: A small number of patients with AMI below 70 years of age are potentially eligible for intestinal transplantation.


Assuntos
Isquemia Mesentérica , Síndrome do Intestino Curto , Humanos , Isquemia Mesentérica/cirurgia , Isquemia Mesentérica/complicações , Estudos Retrospectivos , Intestino Delgado/cirurgia , Síndrome do Intestino Curto/cirurgia , Síndrome do Intestino Curto/complicações , Necrose/etiologia
18.
Rev Esp Enferm Dig ; 115(4): 217-218, 2023 04.
Artigo em Inglês | MEDLINE | ID: mdl-36688443

RESUMO

Portal pneumatosis has been considered an ominous sign associated with intestinal ischemia, with a mortality rate of up to 90% as long as it is associated with sepsis. However, the prognosis of mesenteric ischemia depends on the etiology rather than the presence of portal pneumatosis. We present a patient with portal pneumatosis that disappeared 24 hours after the first surgery, but irreversible ischemic lesions were established in the terminal ileum. It should be noted that the excretion of the intravenous contrast is mainly through the kidneys, and it can be eliminated through alternative routes such as the bile duct or the mucosa of the small intestine (vicariant excretion), especially in patients with renal pathology.


Assuntos
Isquemia Mesentérica , Pneumatose Cistoide Intestinal , Humanos , Isquemia Mesentérica/diagnóstico por imagem , Isquemia Mesentérica/complicações , Veia Porta , Isquemia/etiologia , Isquemia/complicações , Intestino Delgado , Íleo , Pneumatose Cistoide Intestinal/complicações
19.
J Surg Res ; 281: 52-56, 2023 01.
Artigo em Inglês | MEDLINE | ID: mdl-36115149

RESUMO

INTRODUCTION: Although stapled anastomoses have been widely evaluated in the context of the elective surgery, few reports compared manual with stapled anastomoses in patients undergoing emergency surgery. The aim of this study is to compare the outcome of hand-sewn end-to-end anastomoses with stapled side-to-side and stapled end-to-side anastomoses in patients undergoing small bowel resection for acute mesenteric ischemia secondary to intestinal obstruction. METHODS: From January 2015 to June 2021 all the hemodynamically stable patients undergoing emergency surgery with small bowel resection for intestinal obstruction were enrolled in this study. According to surgical technique in performing anastomosis, the patients were divided into three groups: group 1: hand-sewn end-to-end anastomosis, group 2: stapled end-to-side anastomosis, and group 3: stapled side-to-side anastomosis. RESULTS: Although the anastomosis failure rate was higher in group 3, it was not significantly different between the three groups (P = 0.78: chi-square test). Likewise, no significant differences in the median hospital stay were found between the patients' groups (P = 0.87: Kruskal-Wallis test). The median operating time was similar in patients undergoing stapled anastomoses and was significantly higher in patients undergoing hand-sewn anastomoses (P = 0.0009: Kruskal-Wallis test). CONCLUSIONS: In patients undergoing emergency small bowel resection for complicated intestinal obstruction, a similar outcome in terms of dehiscence rate and hospital stay can be achieved performing stapled or hand-sewn anastomoses, even if restoring the intestinal continuity with stapled technique is associated with lower operating time.


Assuntos
Obstrução Intestinal , Isquemia Mesentérica , Humanos , Grampeamento Cirúrgico/métodos , Técnicas de Sutura , Isquemia Mesentérica/complicações , Isquemia Mesentérica/cirurgia , Anastomose Cirúrgica/efeitos adversos , Anastomose Cirúrgica/métodos , Obstrução Intestinal/etiologia , Obstrução Intestinal/cirurgia
20.
Can Assoc Radiol J ; 74(1): 160-171, 2023 02.
Artigo em Inglês | MEDLINE | ID: mdl-35544414

RESUMO

Acute mesenteric ischemia (AMI) is an uncommon yet highly lethal cause of acute abdomen in the emergency setting. Computed tomography (CT) imaging, in particular a biphasic protocol consisting of angiographic and venous phase scans, is widely used to corroborate non-specific clinical findings when suspicions of AMI are high. Techniques such as low kilovoltage peak scanning, dual energy acquisition, or a combined arterial/enteric phase can improve iodine conspicuity and evaluation of bowel enhancement. Biphasic CT with CT angiography is mandatory to directly assess for the 3 primary etiologies of AMI-arterial, venous, and non-occlusive mesenteric ischemia (NOMI), and the CT angiographic findings may be the first visible in the disease. In addition, numerous non-vascular CT findings have also been reported. Bowel wall thickening, mesenteric stranding, and ascites are common but non-specific findings that correlate poorly with disease severity. Pneumatosis intestinalis and portomesenteric venous gas, while not pathognomonic for ischemia, are highly specific in cases of high clinical suspicion. Bowel wall hypoenhancement is an early and specific sign but requires a protocol optimizing iodine conspicuity to confidently identify. Finally, intraperitoneal free air and solid organ infarcts are also highly specific ancillary findings in AMI. AMI occurs as a complication in 10% of small bowel obstruction (SBO) patients, and understanding imaging findings of ischemia in the context of SBO is necessary to aid in treatment planning and reduce over- and under-diagnosis of strangulation. Familiarity with the imaging features of ischemia by radiologists is vital to establish an early diagnosis before irreversible necrosis occurs.


Assuntos
Obstrução Intestinal , Isquemia Mesentérica , Humanos , Isquemia Mesentérica/diagnóstico por imagem , Isquemia Mesentérica/complicações , Intestinos/diagnóstico por imagem , Tomografia Computadorizada por Raios X/métodos , Intestino Delgado , Isquemia/diagnóstico por imagem , Isquemia/complicações , Estudos Retrospectivos , Doença Aguda
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